Endocrine Abstracts

Introduction: Metreleptin, a recombinant analogue of leptin, is the only drug available for the treatment of generalized or partial lipodystrophy. Familial partial lipodystrophy (FPL) is a rare genetic disorder characterized by selective loss of subcutaneous adipose tissue, ectopic fat deposition, decreased leptin levels, and varying metabolic disorders, which in some patients can be quite severe and life-threatening. We present here such a woman with FPL who is treated with m...

Introduction: Eating habits, food choices and exercise affect glycaemic control in patients with Type 1 Diabetes Mellitus (T1DM). The purpose of this study was to evaluate eating behaviors, food choices and the level of physical activity in patients with T1DM.Methods/design: A random sample of 84 patients (M/F: 31/53) with T1DM, aged 34+11.9 years, living in central Greece, were individually interviewed. Food consumption was assessed by a semi-q...

Introduction: Pituicytoma is a rare, primary benign, tumor of the sellar and suprasellar regions which is arising from pituicytes of the neurohypophysis and infundibulum and mainly affects middle age adults. We present here such a casePresentation: A 64-years-old man was referred to our clinic. For further investigation of a sellar lesion with suprasellar extension. The patient underwent investigations due to visual disturbances which he noticed initiall...

Introduction: Obesity is rising worldwide and the number overweight or obese patients with type 1 diabetes mellitus (T1DM) is increased and eating habits (EH) and physical activity (PA) play an important role on glycemic control and weight gain. The aim of the present study was to examine the EH and the exercise level in patients with T1DM and their relation to body weight.Methods: 126 patients with T1DM (55/126 males, 71/126 females) attending our outpa...

Introduction: Aniridia is a rare congenital condition which is characterized by a complete or partial absence of the iris and fovea and malformations of the lens and anterior chamber. It is usually related to mutations in PAX6, a member of a multigene family of transcription factors, which is important for the development of the nervous system, the eyes and also the endocrine pancreas and it is found to be associated with mild glucose intolerance. Complete loss of insulin secr...

Introduction: Pancreatic diabetes is a special category of diabetes due to diseases of the exocrine pancreas, characterized by both insulin and glucagon deficiency and clinically could be very challenging to control. We present a case of a woman with pancreatic diabetes treated with sensor augmented pump therapy after undergoing total pancreatectomy for a nonfunctional pancreatic neuroendocrine tumor (NET).Presentation: A sixty-one years old woman underw...

Introduction: Hyperglycemia in type 1 diabetes mellitus (T1DM) is an important determinant of bone health. However, data on the effect of glycemic changes on bone metabolism are limited. The aim of this study was to evaluate BMD in patients with T1DM in relation to changes of glycemic control.Methods/Design: We studied 118 uncomplicated patients with T1DM (GroupD) (mean age: 30.12+8.78years, F/M: 65/53) and 94 healthy controls (GroupC) matched for age, s...

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), pho...

Introduction: Data on Vitamin B12 deficiency and its relationship with Gestational Diabetes Mellitus (GDM) andpregnancy outcomes are limited. The aim of the present study is to determine, in pregnant women with GDM, the association between Vitamin B12 levels and glycemic control, as well as with pregnancy outcomes.Methods: We studied 44 women with GDM, mean age 31.9 ± 5.8 years old, at the second trimester and at labor and measured weight, height, b...

IntroductionIn this study we present data on the long-term outcomes of treatment of patients with moderate and severe GO.Methods98 patients with GO attending our clinic for the last 13 years and received treatment for moderate to severe GO were evaluated for their long-term response to treatment. Initial decision for treatment was based on activity and severity of the disease, assessed by CAS-score and NOSPEC...